Anti-MDA5 Antibody
Product Sizes
100 ug
£528.00
OAED00400-100UG
About this Product
- SKU:
- OAED00400
- Additional Names:
- AGS7;CADM-140 autoantigen;clinically amyopathic dermatomyositis autoantigen 140 kDa;DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide;helicard;helicase with 2 CARD domains;Hlcd;IDDM19;interferon-induced helicase C domain-containing protein 1;Interferon-induced with helicase C domain protein 1;MDA5;MDA-5;melanoma differentiation-associated gene 5;melanoma differentiation-associated protein 5;murabutide down-regulated protein;RIG-I-like receptor 2;RLR-2;RNA helicase-DEAD box protein 116;SGMRT1.
- translate.label.attr.clone:
- 1B6
- Clonality:
- Monoclonal
- Extra Details:
- Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include mRNA lacking 2'-O-methylation at their 5' cap and long-dsRNA (>1 kb in length). Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes; including interferons (IFNs); IFN-alpha and IFN-beta. Responsible for detecting the Picornaviridae family members such as encephalomyocarditis virus (EMCV) and mengo encephalomyocarditis virus (ENMG). Can also detect other viruses such as dengue virus (DENV); west Nile virus (WNV); and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome; such as vaccinia virus. Plays an important role in amplifying innate immune signaling through recognition of RNA metabolites that are produced during virus infection by ribonuclease L (RNase L). May play an important role in enhancing natural killer cell function and may be involved in growth inhibition and apoptosis in several tumor cell lines.
- Gene Details:
- interferon induced with helicase C domain 1
- Host:
- Mouse
- Immunogen:
- Recombinant human MDA5 (melanoma differentiation-associated gene 5) (aa 78-555).
- Isotype:
- IgG1
- Protein Details:
- Interferon-induced helicase C domain-containing protein 1
- Purification:
- Protein G-affinity purified.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Long Term Storage : -20C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
