Anti-Cardif
Product Sizes
100 ug
£706.00
OAED00260-100UG
About this Product
- SKU:
- OAED00260
- Additional Names:
- CARD adapter inducing interferon beta;CARD adaptor inducing IFN-beta;CARDIF;IFN-B promoter stimulator 1;interferon beta promoter stimulator protein 1;IPS1;IPS-1;mitochondrial antiviral-signaling protein;putative NF-kappa-B-activating protein 031N;virus-induced signaling adaptor;virus-induced-signaling adapter;VISA.
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- Required for innate immune defense against viruses. Acts downstream of DHX33; DDX58/RIG-I and IFIH1/MDA5; which detect intracellular dsRNA produced during viral replication; to coordinate pathways leading to the activation of NF-kappa-B; IRF3 and IRF7; and to the subsequent induction of antiviral cytokines such as IFN-beta and RANTES (CCL5). Peroxisomal and mitochondrial MAVS act sequentially to create an antiviral cellular state. Upon viral infection; peroxisomal MAVS induces the rapid interferon-independent expression of defense factors that provide short-term protection; whereas mitochondrial MAVS activates an interferon-dependent signaling pathway with delayed kinetics; which amplifies and stabilizes the antiviral response. May activate the same pathways following detection of extracellular dsRNA by TLR3. May protect cells from apoptosis.
- Gene Details:
- mitochondrial antiviral signaling protein
- Host:
- Rabbit
- Immunogen:
- Recombinant human Cardif (CARD adapter inducing interferon-beta) (aa 160-450).
- Protein Details:
- Mitochondrial antiviral-signaling protein
- Purification:
- Protein A -- affinity purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store short-term at 4°C; long-term at -20°C. Avoid freeze/thaw cycles. Stable for at least 1 year after receipt when stored at -20°C.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
