Anti-RAIDD
Product Sizes
50 ug
£441.00
OAED00256-50UG
About this Product
- SKU:
- OAED00256
- Additional Names:
- MRT34; RAIDD
- Clonality:
- Polyclonal
- Concentration:
- 1mg/ml
- Extra Details:
- RAIDD (RIP-associated ICH-1 homologous protein with a death domain) is an adaptor molecule that mediates the action of cysteine proteases involved in apoptosis. In human cell lines; the caspase-2 adaptor RAIDD interacts selectively with caspase-2 through its caspase recrui™ent domain (CARD) and leads to caspase-2-dependent death. RAIDD overexpression induced caspase-2; CARD- and caspase-9-dependent apoptosis of PC12 cells and sympathetic neurons. Apoptosis correlated with the formation of discrete perinuclear aggregates. Both death and aggregates required the expression of full-length RAIDD. It has been reported that activation of caspase-2 occurs in a complex that contains the death domain–containing protein PIDD; whose expression is induced by p53; and the adaptor protein RAIDD.
- Host:
- Rabbit
- Immunogen:
- Recombinant human RAIDD (aa 1-199).
- Protein Details:
- Death domain-containing protein CRADD
- Purity:
- Affinity purified.<br/>
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Long Term Storage : -20C
Short Term Storage : +4C
Handling : Avoid freeze/thaw cycles. - Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
