Anti-Estrogen receptor
Product Sizes
50 ug
£376.00
OAED00222-50UG
About this Product
- SKU:
- OAED00222
- Additional Names:
- E2 receptor alpha;ER;Era;ER-alpha;ESR;ESRA;estradiol receptor;estrogen nuclear receptor alpha;estrogen receptor;estrogen receptor alpha E1-E2-1-2;estrogen receptor alpha E1-N2-E2-1-2;ESTRR;NR3A1;nuclear receptor subfamily 3 group A member 1;oestrogen receptor alpha.
- translate.label.attr.clone:
- h-151
- Clonality:
- Monoclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors; such as AP-1/c-Jun; c-Fos; ATF-2; Sp1 and Sp3; to mediate ERE-independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial association with multiprotein coactivator complexes through LXXLL motifs of their respective components. Mutual transrepression occurs between the estrogen receptor (ER) and NF-kappa-B in a cell-type specific manner. Decreases NF-kappa-B DNA-binding activity and inhibits NF-kappa-B-mediated transcription from the IL6 promoter and displace RELA/p65 and associated coregulators from the promoter. Recruited to the NF-kappa-B response element of the CCL2 and IL8 promoters and can displace CREBBP. Present with NF-kappa-B components RELA/p65 and NFKB1/p50 on ERE sequences. Can also act synergistically with NF-kappa-B to activate transcription involving respective recruitment adjacent response elements; the function involves CREBBP. Can activate the transcriptional activity of TFF1. Also mediates membrane-initiated estrogen signaling involving various kinase cascades. Isoform 3 is involved in activation of NOS3 and endothelial nitric oxide production. Isoforms lacking one or several functional domains are thought to modulate transcriptional activity by competitive ligand or DNA binding and/or heterodimerization with the full-length receptor. Essential for MTA1-mediated transcriptional regulation of BRCA1 and BCAS3. Isoform 3 can bind to ERE and inhibit isoform 1.
- Gene Details:
- estrogen receptor 1
- Host:
- Mouse
- Immunogen:
- Synthetic peptide corresponding to the sequence of human Estrogen Receptor; conjugated to KLH.
- Isotype:
- IgG1
- Protein Details:
- Estrogen receptor
- Purification:
- Protein G affinity purified.
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store long term at -20C. Avoid freeze/thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
