HSP90AB1 Antibody
Product Sizes
50 ug
£348.00
OAED00195-50UG
About this Product
- SKU:
- OAED00195
- Additional Names:
- D6S182;heat shock 84 kDa;heat shock 90kD protein 1; beta;heat shock protein 90 kDa;heat shock protein 90kDa alpha (cytosolic); class B member 1;heat shock protein 90kDa alpha family class B member 1;heat shock protein HSP 90-beta;HSP84;HSP90B;HSP90-beta;HSPC2;HSPCB.
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- Molecular chaperone that promotes the maturation; structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins; thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition; ATPase cycle and chaperone function (PubMed:16478993; PubMed:19696785). Engages with a range of client protein classes via its interaction with various co-chaperone proteins or complexes; that act as adapters; simultaneously able to interact with the specific client and the central chaperone itself. Recruitment of ATP and co-chaperone followed by client protein forms a functional chaperone. After the completion of the chaperoning process; properly folded client protein and co-chaperone leave HSP90 in an ADP-bound partially open conformation and finally; ADP is released from HSP90 which acquires an open conformation for the next cycle (PubMed:27295069; PubMed:26991466). Apart from its chaperone activity; it also plays a role in the regulation of the transcription machinery. HSP90 and its co-chaperones modulate transcription at least at three different levels. In the first place; they alter the steady-state levels of certain transcription factors in response to various physiological cues. Second; they modulate the activity of certain epigenetic modifiers; such as histone deacetylases or DNA methyl transferases; and thereby respond to the change in the environment. Third; they participate in the eviction of histones from the promoter region of certain genes and thereby turn on gene expression (PubMed:25973397). Antagonizes STUB1-mediated inhibition of TGF-beta signaling via inhibition of STUB1-mediated SMAD3 ubiquitination and degradation (PubMed:24613385). Promotes cell differentiation by chaperoning BIRC2 and thereby protecting from auto-ubiquitination and degradation by the proteasomal machinery (PubMed:18239673). Main chaperone that is involved in the phosphorylation/activation of the STAT1 by chaperoning both JAK2 and PRKCE under heat shock and in turn; activates its own transcription (PubMed:20353823).
- Gene Details:
- heat shock protein 90 alpha family class B member 1
- Host:
- Rabbit
- Immunogen:
- Recombinant human HSP90beta.
- Molecular Weight:
- 90 kDa
- Protein Details:
- Heat shock protein HSP 90-beta
- Purification:
- Protein A affinity purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Shipped on Blue Ice. For long term storage; store at -20C. Avoid freeze/thaw cycles.
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
