Anti-MEK1 Antibody
Product Sizes
100 ug
£550.00
OAED00083-100UG
About this Product
- SKU:
- OAED00083
- Additional Names:
- CFC3;dual specificity mitogen-activated protein kinase kinase 1;ERK activator kinase 1;MAPK/ERK kinase 1;MAPKK 1;MAPKK1;MEK 1;MEK1;MEL;MKK1;PRKMK1;protein kinase; mitogen-activated; kinase 1 (MAP kinase kinase 1).
- Clonality:
- Polyclonal
- Extra Details:
- Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Binding of extracellular ligands such as growth factors; cytokines and hormones to their cell-surface receptors activates RAS and this initiates RAF1 activation. RAF1 then further activates the dual-specificity protein kinases MAP2K1/MEK1 and MAP2K2/MEK2. Both MAP2K1/MEK1 and MAP2K2/MEK2 function specifically in the MAPK/ERK cascade; and catalyze the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in the extracellular signal-regulated kinases MAPK3/ERK1 and MAPK1/ERK2; leading to their activation and further transduction of the signal within the MAPK/ERK cascade. Depending on the cellular context; this pathway mediates diverse biological functions such as cell growth; adhesion; survival and differentiation; predominantly through the regulation of transcription; metabolism and cytoskeletal rearrangements. One target of the MAPK/ERK cascade is peroxisome proliferator-activated receptor gamma (PPARG); a nuclear receptor that promotes differentiation and apoptosis. MAP2K1/MEK1 has been shown to export PPARG from the nucleus. The MAPK/ERK cascade is also involved in the regulation of endosomal dynamics; including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis.
- Gene Details:
- mitogen-activated protein kinase kinase 1
- Host:
- Rabbit
- Immunogen:
- Synthetic peptide corresponding to the sequence near the N-terminus of human MEK1. The sequence is completely conserved in mouse; rat; hamster; rabbit and Xenopus.
- Protein Details:
- Dual specificity mitogen-activated protein kinase kinase 1
- Purity:
- Protein A affinity purified.<br/>
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Long Term Storage : -20C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
