HLA Class II
Product Sizes
2 mL
£641.00
OADB00299-2ML
About this Product
- SKU:
- OADB00299
- Additional Names:
- DQA1; DQ-A1; CELIAC1; HLA-DQA
- translate.label.attr.clone:
- B-K27
- Clonality:
- Monoclonal
- Concentration:
- 200 tests/2mL
- Extra Details:
- HLA-DQA1 belongs to the HLA class II alpha chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DQA) and a beta chain (DQB); both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B Lymphocytes; dendritic cells; macrophages). The alpha chain is approximately 33-35 kDa. It is encoded by 5 exons; exon 1 encodes the leader peptide; exons 2 and 3 encode the two extracellular domains; and exon 4 encodes the transmembrane domain and the cytoplasmic tail. Within the DQ molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities; resulting in up to four different molecules. Typing for these polymorphisms is routinely done for bone marrow transplantation.
- Gene Details:
- major histocompatibility complex; class II; DQ alpha 2
- Host:
- Mouse
- Isotype:
- Mouse IgG2a
- Molecular Weight:
- 28 kDa
- Protein Details:
- HLA class II histocompatibility antigen; DQ alpha 1 chain; HLA class II histocompatibility antigen; DQ alpha 2 chain
- Purification:
- Ion exchange chromatography
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Stable at +2-8C for 12 months. For longer storage; freeze aliquots
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
