CD95 Antibody
Product Sizes
200 uL
£608.00
OADB00269-200UL
About this Product
- SKU:
- OADB00269
- Additional Names:
- APT1; CD95; FAS1; APO-1; FASTM; ALPS1A; TNFRSF6
- translate.label.attr.clone:
- B-G27
- Clonality:
- Monoclonal
- Concentration:
- 1 ug/uL
- Extra Details:
- The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death; and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD); caspase 8; and caspase 10. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade; and leads to apoptosis. This receptor has been also shown to activate NF-kappaB; MAPK3/ERK1; and MAPK8/JNK; and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described; some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.
- Gene Details:
- Fas cell surface death receptor
- Host:
- Human
- Isotype:
- Mouse IgG2a
- Molecular Weight:
- 38 kDa
- Protein Details:
- tumor necrosis factor receptor superfamily member 6
- Purification:
- Ion exchange chromatography
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Stable at +2-8C for 12 months. For longer storage; freeze aliquots
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
