TOP1 Antibody
Product Sizes
100ul
£333.00
OACD07943-100UL
1ml
£933.00
OACD07943-1ML
About this Product
- SKU:
- OACD07943
- Additional Names:
- DNA topoisomerase 1;DNA topoisomerase I;Scl-70 antigen;TOPI;topoisomerase (DNA) I;type I DNA topoisomerase.
- Clonality:
- Polyclonal
- Concentration:
- 0.5 mg/ml
- Extra Details:
- Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme; resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then rotates around the intact phosphodiester bond on the opposing strand; thus removing DNA supercoils. Finally; in the religation step; the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity). Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. Involved in the circadian transcription of the core circadian clock component ARNTL/BMAL1 by altering the chromatin structure around the ROR response elements (ROREs) on the ARNTL/BMAL1 promoter.
- Gene Details:
- DNA topoisomerase I
- Host:
- Rabbit
- Immunogen:
- Range: Met1 - Ser250
- Isotype:
- IgG
- Molecular Weight:
- 91 kDa
- Protein Details:
- DNA topoisomerase 1
- Purification:
- Affinity Purified; Protein A Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
