TLR6 Antibody
Product Sizes
100ul
£311.00
OACD07818-100UL
1ml
£853.00
OACD07818-1ML
About this Product
- SKU:
- OACD07818
- Additional Names:
- CD286;toll-like receptor 6.
- Clonality:
- Polyclonal
- Concentration:
- 0.5 mg/ml
- Extra Details:
- Participates in the innate immune response to Gram-positive bacteria and fungi. Specifically recognizes diacylated and; to a lesser extent; triacylated lipopeptides (PubMed:20037584). In response to diacylated lipopeptides; forms the activation cluster TLR2:TLR6:CD14:CD36; this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211). Acts via MYD88 and TRAF6; leading to NF-kappa-B activation; cytokine secretion and the inflammatory response. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2); soluble tuberculosis factor (STF); phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2 (PubMed:11441107). In complex with TLR4; promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context; the initial signal is provided by oxLDL- or amyloid-beta 42-binding to CD36. This event induces the formation of a heterodimer of TLR4 and TLR6; which is rapidly internalized and triggers inflammatory response; leading to the NF-kappa-B-dependent production of CXCL1; CXCL2 and CCL9 cytokines; via MYD88 signaling pathway; and CCL5 cytokine; via TICAM1 signaling pathway; as well as IL1B secretion (PubMed:11441107; PubMed:20037584).
- Gene Details:
- toll like receptor 6
- Host:
- Rabbit
- Immunogen:
- Range: Tyr608 - Ser796
- Isotype:
- IgG
- Molecular Weight:
- 56 kDa
- Protein Details:
- Toll-like receptor 6
- Purification:
- Affinity Purified; Protein A Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
