SSRP1 Antibody
Product Sizes
100ul
£311.00
OACD07512-100UL
1ml
£847.00
OACD07512-1ML
About this Product
- SKU:
- OACD07512
- Additional Names:
- chromatin-specific transcription elongation factor 80 kDa subunit;cisplatin-DNA SSRP;facilitates chromatin remodeling 80 kDa subunit;facilitates chromatin transcription complex 80 kDa subunit;facilitates chromatin transcription complex subunit SSRP1;FACT;FACT 80 kDa subunit;FACT complex subunit SSRP1;FACT80;FACTp80;high mobility group box;hSSRP1;recombination signal sequence recognition protein 1;Structure-specific recognition protein 1;T160.
- Clonality:
- Polyclonal
- Concentration:
- 0.5 mg/ml
- Extra Details:
- Component of the FACT complex; a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation; DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome; then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Binds specifically to double-stranded DNA and at low levels to DNA modified by the antitumor agent cisplatin. May potentiate cisplatin-induced cell death by blocking replication and repair of modified DNA. Also acts as a transcriptional coactivator for p63/TP63.
- Gene Details:
- structure specific recognition protein 1
- Host:
- Rabbit
- Immunogen:
- Range: Glu6 - Pro246
- Isotype:
- IgG
- Molecular Weight:
- 81 kDa
- Protein Details:
- FACT complex subunit SSRP1
- Purification:
- Affinity Purified; Protein A Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
