SIGLEC10 Antibody
Product Sizes
100ul
£333.00
OACD07285-100UL
1ml
£933.00
OACD07285-1ML
About this Product
- SKU:
- OACD07285
- Additional Names:
- PRO940;sialic acid binding Ig-like lectin 10 Ig-like lectin 7;sialic acid-binding Ig-like lectin 10;SIGLEC-10;siglec-like gene 2;siglec-like protein 2;SLG2.
- Clonality:
- Polyclonal
- Concentration:
- 0.5 mg/ml
- Extra Details:
- Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2;3- or alpha-2;6-linked sialic acid (By similarity). The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response; seems to act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules (PubMed:11284738; PubMed:12163025). Involved in negative regulation of B-cell antigen receptor signaling. The inhibition of B cell activation is dependent on PTPN6/SHP-1 (By similarity). In association with CD24 may be involved in the selective suppression of the immune response to danger-associated molecular patterns (DAMPs) such as HMGB1; HSP70 and HSP90 (By similarity). In association with CD24 may regulate the immune repsonse of natural killer (NK) cells (PubMed:25450598). Plays a role in the control of autoimmunity (By similarity). During initiation of adaptive immune responses by CD8-alpha(+) dendritic cells inhibits cross-presentation by impairing the formation of MHC class I-peptide complexes. The function seems to implicate recruitment of PTPN6/SHP-1; which dephosphorylates NCF1 of the NADPH oxidase complex consequently promoting phagosomal acidification (By similarity).
- Gene Details:
- sialic acid binding Ig like lectin 10
- Host:
- Rabbit
- Immunogen:
- Range: Met571 - Gln697
- Isotype:
- IgG
- Molecular Weight:
- 21 kDa
- Protein Details:
- Sialic acid-binding Ig-like lectin 10
- Purification:
- Affinity Purified; Protein A Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
