POLA1 Antibody
Product Sizes
100ul
£333.00
OACD06616-100UL
1ml
£933.00
OACD06616-1ML
About this Product
- SKU:
- OACD06616
- Additional Names:
- DNA polymerase alpha catalytic subunit;DNA polymerase alpha catalytic subunit p180;NSX;p180;POLA;polymerase (DNA directed); alpha 1; catalytic subunit;polymerase (DNA) alpha 1; catalytic subunit;polymerase (DNA-directed); alpha (70kD);VEODS.
- Clonality:
- Polyclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- Plays an essential role in the initiation of DNA replication. During the S phase of the cell cycle; the DNA polymerase alpha complex (composed of a catalytic subunit POLA1/p180; a regulatory subunit POLA2/p70 and two primase subunits PRIM1/p49 and PRIM2/p58) is recruited to DNA at the replicative forks via direct interactions with MCM10 and WDHD1. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. These primers are initially extended by the polymerase alpha catalytic subunit and subsequently transferred to polymerase delta and polymerase epsilon for processive synthesis on the lagging and leading strand; respectively. The reason this transfer occurs is because the polymerase alpha has limited processivity and lacks intrinsic 3' exonuclease activity for proofreading error; and therefore is not well suited for replicating long complexes. In the cytosol; responsible for a substantial proportion of the physiological concentration of cytosolic RNA:DNA hybrids; which are necessary to prevent spontaneous activation of type I interferon responses (PubMed:27019227).
- Gene Details:
- DNA polymerase alpha 1; catalytic subunit
- Host:
- Rabbit
- Immunogen:
- Range: Gly1240 - Ser1462
- Isotype:
- IgG
- Molecular Weight:
- 166 kDa
- Protein Details:
- DNA polymerase alpha catalytic subunit
- Purification:
- Affinity Purified; Protein A Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
