PIAS3 Antibody
Product Sizes
100ul
£333.00
OACD06473-100UL
1ml
£933.00
OACD06473-1ML
About this Product
- SKU:
- OACD06473
- Additional Names:
- E3 SUMO-protein ligase PIAS3;E3 SUMO-protein transferase PIAS3;protein inhibitor of activated STAT protein 3;zinc finger; MIZ-type containing 5;ZMIZ5.
- Clonality:
- Polyclonal
- Concentration:
- 0.5 mg/ml
- Extra Details:
- Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase; stabilizing the interaction between UBE2I and the substrate; and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways; including the STAT pathway and the steroid hormone signaling pathway. Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation (PubMed:21965678; PubMed:9388184). Sumoylates CCAR2 which promotes its interaction with SIRT1 (PubMed:25406032). Diminishes the sumoylation of ZFHX3 by preventing the colocalization of ZFHX3 with SUMO1 in the nucleus (PubMed:24651376).
- Gene Details:
- protein inhibitor of activated STAT 3
- Host:
- Rabbit
- Immunogen:
- Range: Val11 - Leu280
- Isotype:
- IgG
- Molecular Weight:
- 68 kDa
- Protein Details:
- E3 SUMO-protein ligase PIAS3
- Purification:
- Affinity Purified; Protein A Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
