MST1R Antibody
Product Sizes
100ul
£326.00
OACD05725-100UL
1ml
£912.00
OACD05725-1ML
About this Product
- SKU:
- OACD05725
- Additional Names:
- CD136;CDw136;friend virus susceptibility 2;Fv;Fv-;Fv2;Fv-2;macrophage-stimulating protein receptor;MSP receptor;p185-Ron;PTK;PTK8;receptor protein tyrosine kinase; c-met-related;Ron;ST;stem cell-derived tyrosine kinase;STK.
- Clonality:
- Polyclonal
- Concentration:
- 0.5 mg/ml
- Extra Details:
- Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival; migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand; interacts with the PI3-kinase subunit PIK3R1; PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK; PI3 kinase-AKT; or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration; proliferation as well as survival at the wound site. Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively; RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand.
- Gene Details:
- macrophage stimulating 1 receptor (c-met-related tyrosine kinase)
- Host:
- Rabbit
- Immunogen:
- Range: Ile89 - Ser275
- Isotype:
- IgG
- Molecular Weight:
- 151 kDa
- Protein Details:
- Macrophage-stimulating protein receptor
- Purification:
- Affinity Purified; Protein A Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
