CCL20 Antibody
Product Sizes
100ul
£261.00
OACD05602-100UL
1ml
£641.00
OACD05602-1ML
About this Product
- SKU:
- OACD05602
- Additional Names:
- beta-chemokine exodus-1;CC chemokine LARC;CC chemokine ST38;C-C motif chemokine 20;CKb4;exodus;exodus-1;LARC;liver and activation-regulated chemokine;macrophage inflammatory protein 3 alpha;MI;MIP;MIP-3;MIP-3[a];MIP3A;MIP-3A;MIP-3-alpha;Scya;Scya20;small inducible cytokine subfamily A20;small-inducible cytokine A20;ST3;ST38.
- Clonality:
- Polyclonal
- Concentration:
- 0.5 mg/ml
- Extra Details:
- Acts as a ligand for C-C chemokine receptor CCR6. Signals through binding and activation of CCR6 and induces a strong chemotactic response and mobilization of intracellular calcium ions (PubMed:9862452; PubMed:20068036). The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC); effector/memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions; as well as in pathology; including cancer and autoimmune diseases (PubMed:21376174). CCL20 acts as a chemotactic factor that attracts lymphocytes and; slightly; neutrophils; but not monocytes (By similarity). Involved in the recruitment of both the proinflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation (PubMed:19050256). Required for optimal migration of thymic natural regulatory T cells (nTregs) and DN1 early thymocyte progenitor cells (PubMed:24638065). Positively regulates sperm motility and chemotaxis via its binding to CCR6 which triggers Ca2+ mobilization in the sperm which is important for its motility (PubMed:25122636). May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells (PubMed:10064080).
- Gene Details:
- chemokine (C-C motif) ligand 20
- Host:
- Rabbit
- Immunogen:
- Range: Gln24 - Met97
- Isotype:
- IgG
- Molecular Weight:
- 11 kDa
- Protein Details:
- C-C motif chemokine 20
- Purification:
- Affinity Purified; Protein A Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
