MB21D1 Antibody
Product Sizes
100ul
£359.00
OACD05461-100UL
1ml
£1016.00
OACD05461-1ML
About this Product
- SKU:
- OACD05461
- Additional Names:
- 2'3'-cGAMP synthase;C6orf150;cGAMP synthase;cyclic GMP-AMP synthase;h-cGAS;Mab-21 domain containing 1;mab-21 domain-containing protein 1;MB21D1;protein MB21D1.
- Clonality:
- Polyclonal
- Concentration:
- 0.5 mg/ml
- Extra Details:
- Nucleotidyltransferase that catalyzes the formation of cyclic GMP-AMP (cGAMP) from ATP and GTP (PubMed:23258413; PubMed:23707061; PubMed:23722159; PubMed:24077100; PubMed:25131990). Catalysis involves both the formation of a 2';5' phosphodiester linkage at the GpA step and the formation of a 3';5' phosphodiester linkage at the ApG step; producing c[G(2';5')pA(3';5')p] (PubMed:28363908; PubMed:28214358). Acts as a key cytosolic DNA sensor; the presence of double-stranded DNA (dsDNA) in the cytoplasm being a danger signal that triggers the immune responses (PubMed:28363908). Binds cytosolic DNA directly; leading to activation and synthesis of cGAMP; a second messenger that binds to and activates TMEM173/STING; thereby triggering type-I interferon production (PubMed:28363908; PubMed:28314590). Has antiviral activity by sensing the presence of dsDNA from DNA viruses in the cytoplasm (PubMed:28363908). Also acts as an innate immune sensor of infection by retroviruses; such as HIV-1; by detecting the presence of reverse-transcribed DNA in the cytosol (PubMed:23929945). Detection of retroviral reverse-transcribed DNA in the cytosol may be indirect and be mediated via interaction with PQBP1; which directly binds reverse-transcribed retroviral DNA (PubMed:26046437). Also detects the presence of DNA from bacteria; such as M.tuberculosis (PubMed:26048138). cGAMP can be transferred from producing cells to neighboring cells through gap junctions; leading to promote TMEM173/STING activation and convey immune response to connecting cells (PubMed:24077100). cGAMP can also be transferred between cells by virtue of packaging within viral particles contributing to IFN-induction in newly infected cells in a cGAS-independent but TMEM173/STING-dependent manner (PubMed:26229115). In addition to antiviral activity; also involved in the response to cellular stresses; such as senescence; DNA damage or genome instability (PubMed:28738408; PubMed:28759889). Acts as a regulator of cellular senescence by binding to cytosolic chromatin fragments that are present in senescent cells; leading to trigger type-I interferon production via TMEM173/STING and promote cellular senescence (By similarity). Also involved in the inflammatory response to genome instability and double-stranded DNA breaks: acts by localizing to micronuclei arising from genome instability (PubMed:28738408; PubMed:28759889). Micronuclei; which as frequently found in cancer cells; consist of chromatin surrounded by its own nuclear membrane: following breakdown of the micronuclear envelope; a process associated with chromothripsis; CGAS binds self-DNA exposed to the cytosol; leading to cGAMP synthesis and subsequent activation of TMEM173/STING and type-I interferon production (PubMed:28738408; PubMed:28759889).
- Gene Details:
- cyclic GMP-AMP synthase
- Host:
- Rabbit
- Immunogen:
- Range: Glu225 - Lys407
- Isotype:
- IgG
- Molecular Weight:
- 50 kDa
- Protein Details:
- Cyclic GMP-AMP synthase
- Purification:
- Affinity Purified; Protein A Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
