MAPK10 Antibody
Product Sizes
100ul
£322.00
OACD05432-100UL
1ml
£890.00
OACD05432-1ML
About this Product
- SKU:
- OACD05432
- Additional Names:
- c-Jun N-terminal kinase 3;JNK3;JNK3 alpha protein kinase;JNK3A;MAP kinase 10;MAP kinase p49 3F12;mitogen-activated protein kinase 10;p493F12;p54bSAPK;PRKM10;SAPK1b;stress activated protein kinase beta;stress-activated protein kinase 1b;stress-activated protein kinase JNK3.
- Clonality:
- Polyclonal
- Concentration:
- 0.5 mg/ml
- Extra Details:
- Serine/threonine-protein kinase involved in various processes such as neuronal proliferation; differentiation; migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade; two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn; MAPK10/JNK3 phosphorylates a number of transcription factors; primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the amyloid-beta precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons. Phosphorylates the CLOCK-ARNTL/BMAL1 heterodimer and plays a role in the photic regulation of the circadian clock (PubMed:22441692).
- Gene Details:
- mitogen-activated protein kinase 10
- Host:
- Rabbit
- Immunogen:
- Range: Arg88 - Ala332
- Isotype:
- IgG
- Molecular Weight:
- 32 kDa
- Protein Details:
- Mitogen-activated protein kinase 10
- Purification:
- Affinity Purified; Protein A Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
