LAMP2 Antibody
Product Sizes
100ul
£326.00
OACD05147-100UL
1ml
£912.00
OACD05147-1ML
About this Product
- SKU:
- OACD05147
- Additional Names:
- CD107 antigen-like family member B;CD107b;Lam;Lamp;Lamp II;Lamp-2;Lamp-2a;Lamp-2b;Lamp-2c;LGP-B;lysosomal membrane glycoprotein 2;lysosomal membrane glycoprotein type B;lysosome-associated membrane glycoprotein 2;Mac;Mac3.
- Clonality:
- Polyclonal
- Concentration:
- 0.5 mg/ml
- Extra Details:
- Plays an important role in chaperone-mediated autophagy; a process that mediates lysosomal degradation of proteins in response to various stresses and as part of the normal turnover of proteins with a long biological half-live (PubMed:10972293). Functions by binding target proteins; such as GAPDH and MLLT11; and targeting them for lysosomal degradation (By similarity). Required for the fusion of autophagosomes with lysosomes during autophagy (PubMed:27628032). Cells that lack LAMP2 express normal levels of VAMP8; but fail to accumulate STX17 on autophagosomes; which is the most likely explanation for the lack of fusion between autophagosomes and lysosomes (PubMed:27628032). Required for normal degradation of the contents of autophagosomes (PubMed:10972293; PubMed:12221139). Plays a role in lysosomal protein degradation in response to starvation (PubMed:27628032). Required for efficient MHCII-mediated presentation of exogenous antigens via its function in lysosomal protein degradation; antigenic peptides generated by proteases in the endosomal/lysosomal compartment are captured by nascent MHCII subunits. Is not required for efficient MHCII-mediated presentation of endogenous antigens (By similarity).
- Gene Details:
- lysosomal-associated membrane protein 2
- Host:
- Rabbit
- Immunogen:
- Range: Asn295 - Thr410
- Isotype:
- IgG
- Molecular Weight:
- 46 kDa
- Protein Details:
- Lysosome-associated membrane glycoprotein 2
- Purification:
- Affinity Purified; Protein A Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
