HSPA1L Antibody
Product Sizes
100ul
£344.00
OACD04329-100UL
1ml
£962.00
OACD04329-1ML
About this Product
- SKU:
- OACD04329
- Additional Names:
- heat shock 70 kDa protein 1L;heat shock 70 kDa protein 1-like;heat shock 70 kDa protein 3;heat shock protein 1-like;heat shock protein 70;Heat shock protein 70-1l;HSP70.3;Hsp70-3.
- Clonality:
- Polyclonal
- Concentration:
- 0.5 mg/ml
- Extra Details:
- Molecular chaperone implicated in a wide variety of cellular processes; including protection of the proteome from stress; folding and transport of newly synthesized polypeptides; activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system; ensuring the correct folding of proteins; the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding; ATP hydrolysis and ADP release; mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form; it has a low affinity for substrate proteins. However; upon hydrolysis of the ATP to ADP; it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange; which permits cycles of substrate binding and release. Positive regulator of PRKN translocation to damaged mitochondria.
- Gene Details:
- heat shock protein family A (Hsp70) member 1 like
- Host:
- Rabbit
- Immunogen:
- Range: Met1 - Asp641
- Isotype:
- IgG
- Molecular Weight:
- 71 kDa
- Protein Details:
- Heat shock 70 kDa protein 1-like
- Purification:
- Affinity Purified; Protein A Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
