GLI3 Antibody
Product Sizes
100ul
£344.00
OACD03888-100UL
1ml
£955.00
OACD03888-1ML
About this Product
- SKU:
- OACD03888
- Additional Names:
- add;AI854843;anterior digit pattern deformity;AU023367;Bp;Bph;brachyphalangy;extra toes;GLI3 form of 190 kDa;GLI3 full length protein;GLI3 full-length protein;GLI3-190;GLI3FL;Pdn;polydactyly Nagoya;transcriptional activator GLI3;Xt;zinc finger protein GLI3.
- Clonality:
- Polyclonal
- Concentration:
- 0.5 mg/ml
- Extra Details:
- Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway; and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation; acts as an activator (GLI3A) while GLI3R; its C-terminally truncated form; acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R; rather than the repressor gradient itself or the activator/repressor ratio gradient; specifies limb digit number and identity. In concert with TRPS1; plays a role in regulating the size of the zone of distal chondrocytes; in restricting the zone of PTHLH expression in distal cells and in activating chondrocyte proliferation. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'.
- Gene Details:
- GLI-Kruppel family member GLI3
- Host:
- Rabbit
- Immunogen:
- Range: Ser303 - Glu561
- Isotype:
- IgG
- Molecular Weight:
- 172 kDa
- Protein Details:
- Transcriptional activator GLI3
- Purification:
- Affinity Purified; Protein A Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
