DIAPH1 Antibody
Product Sizes
100ul
£333.00
OACD03047-100UL
1ml
£933.00
OACD03047-1ML
About this Product
- SKU:
- OACD03047
- Additional Names:
- DFNA1;DIA1;Diaphanous-related formin-1;DRF1;hDIA1;LFHL1;protein diaphanous homolog 1;SCBMS.
- Clonality:
- Polyclonal
- Concentration:
- 0.67 mg/ml
- Extra Details:
- Acts in a Rho-dependent manner to recruit PFY1 to the membrane. Required for the assembly of F-actin structures; such as actin cables and stress fibers. Nucleates actin filaments. Binds to the barbed end of the actin filament and slows down actin polymerization and depolymerization. Required for cytokinesis; and transcriptional activation of the serum response factor. DFR proteins couple Rho and Src tyrosine kinase during signaling and the regulation of actin dynamics. Functions as a scaffold protein for MAPRE1 and APC to stabilize microtubules and promote cell migration (By similarity). Has neurite outgrowth promoting activity (By similarity). In hear cells; it may play a role in the regulation of actin polymerization in hair cells. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane; via the regulation of GSK3B activity. In turn; membrane-bound APC allows the localization of the MACF1 to the cell membrane; which is required for microtubule capture and stabilization. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape (PubMed:20937854; PubMed:21834987). Plays a role in brain development (PubMed:24781755).
- Gene Details:
- diaphanous related formin 1
- Host:
- Rabbit
- Immunogen:
- Range: Asp389 - Pro583
- Isotype:
- IgG
- Molecular Weight:
- 139 kDa
- Protein Details:
- Protein diaphanous homolog 1
- Purification:
- Affinity Purified; Protein A Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
