DDB2 Antibody
Product Sizes
100ul
£316.00
OACD02996-100UL
1ml
£868.00
OACD02996-1ML
About this Product
- SKU:
- OACD02996
- Additional Names:
- 2610043A19Rik;Damage-specific DNA-binding protein 2;DNA damage-binding protein 2;p4.
- Clonality:
- Polyclonal
- Concentration:
- 0.5 mg/ml
- Extra Details:
- Required for DNA repair. Binds to DDB1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. The UV-DDB complex preferentially binds to cyclobutane pyrimidine dimers (CPD); 6-4 photoproducts (6-4 PP); apurinic sites and short mismatches. Also appears to function as the substrate recognition module for the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB1-CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1). The DDB1-CUL4-ROC1 complex may ubiquitinate histone H2A; histone H3 and histone H4 at sites of UV-induced DNA damage. The ubiquitination of histones may facilitate their removal from the nucleosome and promote subsequent DNA repair. The DDB1-CUL4-ROC1 complex also ubiquitinates XPC; which may enhance DNA-binding by XPC and promote NER.
- Gene Details:
- damage specific DNA binding protein 2
- Host:
- Rabbit
- Immunogen:
- Range: Lys212 - Leu407
- Isotype:
- IgG
- Molecular Weight:
- 48 kDa
- Protein Details:
- DNA damage-binding protein 2
- Purification:
- Affinity Purified; Protein A Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
