RARRES2 Antibody
Product Sizes
100ul
£311.00
OACD02507-100UL
1ml
£853.00
OACD02507-1ML
About this Product
- SKU:
- OACD02507
- Additional Names:
- chemerin;HP10433;RAR-responsive protein TIG2;retinoic acid receptor responder (tazarotene induced) 2;retinoic acid receptor responder protein 2;tazarotene-induced gene 2 protein;TIG2.
- Clonality:
- Polyclonal
- Concentration:
- 0.5 mg/ml
- Extra Details:
- Adipocyte-secreted protein (adipokine) that regulates adipogenesis; metabolism and inflammation through activation of the chemokine-like receptor 1 (CMKLR1). Its other ligands include G protein-coupled receptor 1 (GPR1) and chemokine receptor-like 2 (CCRL2). Positively regulates adipocyte differentiation; modulates the expression of adipocyte genes involved in lipid and glucose metabolism and might play a role in angiogenesis; a process essential for the expansion of white adipose tissue. Also acts as a proinflammatory adipokine; causing an increase in secretion of proinflammatory and prodiabetic adipokines; which further impair adipose tissue metabolic function and have negative systemic effects including impaired insulin sensitivity; altered glucose and lipid metabolism; and a decrease in vascular function in other tissues. Can have both pro- and anti-inflammatory properties depending on the modality of enzymatic cleavage by different classes of proteases. Acts as a chemotactic factor for leukocyte populations expressing CMKLR1; particularly immature plasmacytoid dendritic cells; but also immature myeloid DCs; macrophages and natural killer cells. Exerts an anti-inflammatory role by preventing TNF/TNFA-induced VCAM1 expression and monocytes adhesion in vascular endothelial cells. The effect is mediated via inhibiting activation of NF-kappa-B and CRK/p38 through stimulation of AKT1/NOS3 signaling and nitric oxide production. Its dual role in inflammation and metabolism might provide a link between chronic inflammation and obesity; as well as obesity-related disorders such as type 2 diabetes and cardiovascular disease. Exhibits an antimicrobial function in the skin.
- Gene Details:
- retinoic acid receptor responder 2
- Host:
- Rabbit
- Immunogen:
- Range: Ala33 - Lys158
- Isotype:
- IgG
- Molecular Weight:
- 19 kDa
- Protein Details:
- Retinoic acid receptor responder protein 2
- Purification:
- Affinity Purified; Protein A Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
