CD8A Antibody
Product Sizes
100ul
£326.00
OACD02357-100UL
1ml
£912.00
OACD02357-1ML
About this Product
- SKU:
- OACD02357
- Additional Names:
- CD8 antigen 32 kDa chain;CD8 antigen; alpha-chain;OX-8 membrane antigen;T-cell surface glycoprotein CD8 alpha chain.
- Clonality:
- Polyclonal
- Concentration:
- 0.5 mg/ml
- Extra Details:
- Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells; functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn; recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production; motility; adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells; the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells.
- Gene Details:
- CD8a molecule
- Host:
- Rabbit
- Immunogen:
- Range: Gly26 - Val236
- Isotype:
- IgG
- Molecular Weight:
- 26 kDa
- Protein Details:
- T-cell surface glycoprotein CD8 alpha chain
- Purification:
- Affinity Purified; Protein A Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
