PPP3CA Antibody
Product Sizes
100ul
£322.00
OACD02160-100UL
1ml
£890.00
OACD02160-1ML
About this Product
- SKU:
- OACD02160
- Additional Names:
- ACCIID;calcineurin A alpha;Calmodulin-dependent calcineurin A subunit alpha isoform;CALN;CALNA;CALNA1;CAM-PRP catalytic subunit;CCN1;CNA1;DEE91;IECEE;IECEE1;PPP2B;protein phosphatase 3 catalytic subunit alpha isozyme;serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform.
- Clonality:
- Polyclonal
- Concentration:
- 0.5 mg/ml
- Extra Details:
- Calcium-dependent; calmodulin-stimulated protein phosphatase which plays an essential role in the transduction of intracellular Ca(2+)-mediated signals (PubMed:15671020; PubMed:18838687; PubMed:19154138; PubMed:23468591). Many of the substrates contain a PxIxIT motif and/or a LxVP motif (PubMed:17498738; PubMed:17502104; PubMed:23468591; PubMed:27974827; PubMed:22343722). In response to increased Ca(2+) levels; dephosphorylates and activates phosphatase SSH1 which results in cofilin dephosphorylation (PubMed:15671020). In response to increased Ca(2+) levels following mitochondrial depolarization; dephosphorylates DNM1L inducing DNM1L translocation to the mitochondrion (PubMed:18838687). Dephosphorylates heat shock protein HSPB1 (By similarity). Dephosphorylates and activates transcription factor NFATC1 (PubMed:19154138). In response to increased Ca(2+) levels; regulates NFAT-mediated transcription probably by dephosphorylating NFAT and promoting its nuclear translocation (PubMed:26248042). Dephosphorylates and inactivates transcription factor ELK1 (PubMed:19154138). Dephosphorylates DARPP32 (PubMed:19154138).
- Gene Details:
- protein phosphatase 3 catalytic subunit alpha
- Host:
- Rabbit
- Immunogen:
- Range: Ile7 - Ser301
- Isotype:
- IgG
- Molecular Weight:
- 32 kDa
- Protein Details:
- Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
- Purification:
- Affinity Purified; Protein A Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
