APC Antibody
Product Sizes
100ul
£355.00
OACD01699-100UL
1ml
£1005.00
OACD01699-1ML
About this Product
- SKU:
- OACD01699
- Additional Names:
- adenomatosis polyposis coli;adenomatous polyposis coli protein;APC; WNT signaling pathway regulator;RATAPC;WNT signaling pathway regulator.
- Clonality:
- Polyclonal
- Concentration:
- 0.99 mg/ml
- Extra Details:
- Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization (By similarity).
- Gene Details:
- APC regulator of WNT signaling pathway
- Host:
- Rabbit
- Immunogen:
- Range: Ala2634 - Val2842
- Isotype:
- IgG
- Molecular Weight:
- 311 kDa
- Protein Details:
- Adenomatous polyposis coli protein
- Purification:
- Affinity Purified; Protein A Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
