AMFR Antibody
Product Sizes
100ul
£344.00
OACD01590-100UL
1ml
£955.00
OACD01590-1ML
About this Product
- SKU:
- OACD01590
- Additional Names:
- AMF receptor;Autocrine motility factor receptor;E3 ubiquitin-protein ligase AMFR;gp7;gp78;RING-type E3 ubiquitin transferase AMFR.
- Clonality:
- Polyclonal
- Concentration:
- 0.5 mg/ml
- Extra Details:
- E3 ubiquitin-protein ligase that mediates the polyubiquitination of a number of proteins such as CD3D; CYP3A4; CFTR and APOB for proteasomal degradation. Component of a VCP/p97-AMFR/gp78 complex that participates in the final step of endoplasmic reticulum-associated degradation (ERAD). The VCP/p97-AMFR/gp78 complex is involved in the sterol-accelerated ERAD degradation of HMGCR through binding to the HMGCR-INSIG complex at the ER membrane and initiating ubiquitination of HMGCR. The ubiquitinated HMGCR is then released from the ER by the complex into the cytosol for subsequent destruction. Also regulates ERAD through the ubiquitination of UBL4A a component of the BAG6/BAT3 complex. Also acts as a scaffold protein to assemble a complex that couples ubiquitination; retranslocation and deglycosylation. Mediates tumor invasion and metastasis (By similarity).
- Gene Details:
- autocrine motility factor receptor
- Host:
- Rabbit
- Immunogen:
- Range: Met456 - Thr639
- Isotype:
- IgG
- Molecular Weight:
- 73 kDa
- Protein Details:
- E3 ubiquitin-protein ligase AMFR
- Purification:
- Affinity Purified; Protein A Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
