ERCC2 Antibody
Product Sizes
100ul
£333.00
OACD01211-100UL
1ml
£933.00
OACD01211-1ML
About this Product
- SKU:
- OACD01211
- Additional Names:
- basic transcription factor 2 80 kDa subunit;BTF2 p80;COFS2;CXPD;DNA excision repair protein ERCC-2;DNA repair protein complementing XP-D cells;EM9;excision repair cross-complementation group 2;excision repair cross-complementing rodent repair deficiency; complementation group 2;general transcription and DNA repair factor IIH helicase subunit XPD;TFIIH;TFIIH 80 kDa subunit;TFIIH basal transcription factor complex 80 kDa subunit;TFIIH basal transcription factor complex helicase subunit;TFIIH basal transcription factor complex helicase XPB subunit;TFIIH basal transcription factor complex helicase XPD subunit;TFIIH p80;TFIIH subunit XPD;TTD;TTD1;xeroderma pigmentosum complementary group D;xeroderma pigmentosum group D-complementing protein;XPD.
- Clonality:
- Polyclonal
- Concentration:
- 0.5 mg/ml
- Extra Details:
- ATP-dependent 5'-3' DNA helicase; component of the general transcription and DNA repair factor IIH (TFIIH) core complex; which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and; when complexed to CAK; in RNA transcription by RNA polymerase II. In NER; TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATP-dependent helicase activity of XPD/ERCC2 is required for DNA opening. In transcription; TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established; TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. XPD/ERCC2 acts by forming a bridge between CAK and the core-TFIIH complex. Involved in the regulation of vitamin-D receptor activity. As part of the mitotic spindle-associated MMXD complex it plays a role in chromosome segregation. Might have a role in aging process and could play a causative role in the generation of skin cancers.
- Gene Details:
- ERCC excision repair 2; TFIIH core complex helicase subunit
- Host:
- Rabbit
- Immunogen:
- Range: Ala404 - Leu637
- Isotype:
- IgG
- Molecular Weight:
- 46 kDa
- Protein Details:
- General transcription and DNA repair factor IIH helicase subunit XPD
- Purification:
- Affinity Purified; Protein A Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
