CIB1 Antibody
Product Sizes
100ul
£333.00
OACD01155-100UL
1ml
£933.00
OACD01155-1ML
About this Product
- SKU:
- OACD01155
- Additional Names:
- calcium and integrin binding 1 (calmyrin);Calcium- and integrin-binding protein;calcium and integrin-binding protein 1;Calmyrin;CIB;CIBP;DNA-dependent protein kinase interacting protein;DNA-PK interaction protein;DNA-PKcs-interacting protein;Kinase-interacting protein;KIP1;PRKDCIP;SIP2-28;SNK-interacting protein 2-28;testicular secretory protein Li 9.
- Clonality:
- Polyclonal
- Concentration:
- 0.5 mg/ml
- Extra Details:
- Calcium-binding protein that plays a role in the regulation of numerous cellular processes; such as cell differentiation; cell division; cell proliferation; cell migration; thrombosis; angiogenesis; cardiac hypertrophy and apoptosis. Involved in bone marrow megakaryocyte differentiation by negatively regulating thrombopoietin-mediated signaling pathway. Participates in the endomitotic cell cycle of megakaryocyte; a form of mitosis in which both karyokinesis and cytokinesis are interrupted. Plays a role in integrin signaling by negatively regulating alpha-IIb/beta3 activation in thrombin-stimulated megakaryocytes preventing platelet aggregation. Up-regulates PTK2/FAK1 activity; and is also needed for the recruitment of PTK2/FAK1 to focal adhesions; it thus appears to play an important role in focal adhesion formation. Positively regulates cell migration on fibronectin in a CDC42-dependent manner; the effect being negatively regulated by PAK1. Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. Down-regulates inositol 1;4;5-trisphosphate receptor-dependent calcium signaling. Involved in sphingosine kinase SPHK1 translocation to the plasma membrane in a N-myristoylation-dependent manner preventing TNF-alpha-induced apoptosis. Regulates serine/threonine-protein kinase PLK3 activity for proper completion of cell division progression. Plays a role in microtubule (MT) dynamics during neuronal development; disrupts the MT depolymerization activity of STMN2 attenuating NGF-induced neurite outgrowth and the MT reorganization at the edge of lamellipodia. Promotes cardiomyocyte hypertrophy via activation of the calcineurin/NFAT signaling pathway. Stimulates calcineurin PPP3R1 activity by mediating its anchoring to the sarcolemma. In ischemia-induced (pathological or adaptive) angiogenesis; stimulates endothelial cell proliferation; migration and microvessel formation by activating the PAK1 and ERK1/ERK2 signaling pathway. Promotes also cancer cell survival and proliferation. May regulate cell cycle and differentiation of spermatogenic germ cells; and/or differentiation of supporting Sertoli cells.
- Gene Details:
- calcium and integrin binding 1
- Host:
- Rabbit
- Immunogen:
- Range: Gly2 - Leu191
- Isotype:
- IgG
- Molecular Weight:
- 22 kDa
- Protein Details:
- Calcium and integrin-binding protein 1
- Purification:
- Affinity Purified; Protein A Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
