POLD1 Antibody
Product Sizes
100ul
£359.00
OACD00922-100UL
1ml
£1016.00
OACD00922-1ML
About this Product
- SKU:
- OACD00922
- Additional Names:
- 3'-5' exodeoxyribonuclease;CDC2;CDC2 homolog;CRCS10;DNA polymerase delta catalytic subunit;DNA polymerase subunit delta p125;MDPL;POLD;polymerase (DNA directed); delta 1; catalytic subunit 125kDa;polymerase (DNA) delta 1; catalytic subunit.
- Clonality:
- Polyclonal
- Concentration:
- 0.66 mg/ml
- Extra Details:
- As the catalytic component of the trimeric (Pol-delta3 complex) and tetrameric DNA polymerase delta complexes (Pol-delta4 complex); plays a crucial role in high fidelity genome replication; including in lagging strand synthesis; and repair. Exhibits both DNA polymerase and 3'- to 5'-exonuclease activities (PubMed:16510448; PubMed:19074196; PubMed:20334433; PubMed:24035200; PubMed:24022480). Requires the presence of accessory proteins POLD2; POLD3 and POLD4 for full activity. Depending upon the absence (Pol-delta3) or the presence of POLD4 (Pol-delta4); displays differences in catalytic activity. Most notably; expresses higher proofreading activity in the context of Pol-delta3 compared with that of Pol-delta4 (PubMed:19074196; PubMed:20334433). Although both Pol-delta3 and Pol-delta4 process Okazaki fragments in vitro; Pol-delta3 may be better suited to fulfill this task; exhibiting near-absence of strand displacement activity compared to Pol-delta4 and stalling on encounter with the 5'-blocking oligonucleotides. Pol-delta3 idling process may avoid the formation of a gap; while maintaining a nick that can be readily ligated (PubMed:24035200). Along with DNA polymerase kappa; DNA polymerase delta carries out approximately half of nucleotide excision repair (NER) synthesis following UV irradiation (PubMed:20227374). Under conditions of DNA replication stress; in the presence of POLD3 and POLD4; may catalyze the repair of broken replication forks through break-induced replication (BIR) (PubMed:24310611). Involved in the translesion synthesis (TLS) of templates carrying O6-methylguanine or abasic sites (PubMed:19074196).
- Gene Details:
- DNA polymerase delta 1; catalytic subunit
- Host:
- Rabbit
- Immunogen:
- Range: Met41 - Phe254
- Isotype:
- IgG
- Molecular Weight:
- 124 kDa
- Protein Details:
- DNA polymerase delta catalytic subunit
- Purification:
- Affinity Purified; Protein A Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
