S100A12 Antibody
Product Sizes
100ul
£301.00
OACD00279-100UL
200ul
£387.00
OACD00279-200UL
1ml
£814.00
OACD00279-1ML
About this Product
- SKU:
- OACD00279
- Additional Names:
- CAAF1;CAGC;calcitermin;calcium-binding protein in amniotic fluid 1;calgranulin C;Calgranulin-C;CGRP;ENRAGE;EN-RAGE;extracellular newly identified RAGE-binding protein;migration inhibitory factor-related protein 6;MRP6;MRP-6;neutrophil S100 protein;p6;protein S100-A12;S100 calcium-binding protein A12.
- translate.label.attr.clone:
- 15#
- Clonality:
- Monoclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- S100A12 is a calcium-; zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes; promotion of cytokine and chemokine production; and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leading to production of proinflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. Acts as a monocyte and mast cell chemoattractant. Can stimulate mast cell degranulation and activation which generates chemokines; histamine and cytokines inducing further leukocyte recruitment to the sites of inflammation. Can inhibit the activity of matrix metalloproteinases; MMP2; MMP3 and MMP9 by chelating Zn(2+) from their active sites. Possesses filariacidal and filariastatic activity. Calcitermin possesses antifungal activity against C.albicans and is also active against E.coli and P.aeruginosa but not L.monocytogenes and S.aureus.
- Gene Details:
- S100 calcium binding protein A12
- Host:
- Mouse
- Immunogen:
- <a href='//www.avivasysbio.com/s100a12-recombinant-protein-opcd06779.html' target='_blank'>S100A12 Recombinant Protein (OPCD06779)</a><br/> Recombinant S100A12 (Met1~Glu92) expressed in E. coli
- Isotype:
- IgG2b Kappa
- Protein Details:
- Protein S100-A12
- Purification:
- Protein A/G Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Monoclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
