OAS3 Antibody
Product Sizes
50ug
£305.00
OACA10739-50UG
100ug
£463.00
OACA10739-100UG
About this Product
- SKU:
- OACA10739
- Additional Names:
- (2-5')oligo(A) synthase 3;(2-5')oligo(A) synthetase 3;2-5A synthase 3;2-5A synthetase 3;2'-5'-oligoadenylate synthase 3;2'-5'-oligoadenylate synthetase 3; 100kDa;2'-5'oligoadenylate synthetase p100;p100;p100 OAS;p100OAS.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Extra Details:
- Interferon-induced; dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition; it may also play a role in other cellular processes such as apoptosis; cell growth; differentiation and gene regulation. Synthesizes preferentially dimers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA; resulting in the inhibition of protein synthesis; thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Displays antiviral activity against Chikungunya virus (CHIKV); Dengue virus; Sindbis virus (SINV) and Semliki forest virus (SFV).
- Gene Details:
- 2'-5'-oligoadenylate synthetase 3
- Host:
- Rabbit
- Immunogen:
- Recombinant Human 2\'-5\'-oligoadenylate synthase 3 protein (424-565AA)
- Isotype:
- IgG
- Protein Details:
- 2'-5'-oligoadenylate synthase 3
- Purity:
- >95%
- Purification:
- Protein G Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
