STUB1 Antibody
Product Sizes
50ug
£305.00
OACA10723-50UG
100ug
£463.00
OACA10723-100UG
About this Product
- SKU:
- OACA10723
- Additional Names:
- antigen NY-CO-7;carboxy terminus of Hsp70-interacting protein;CHIP;CLL-associated antigen KW-8;E3 ubiquitin-protein ligase CHIP;heat shock protein A binding protein 2 (c-terminal);HSPABP2;NY-CO-7;RING-type E3 ubiquitin transferase CHIP;SCA48;SCAR16;SDCCAG7;serologically defined colon cancer antigen 7;STIP1 homology and U box-containing protein 1;STIP1 homology and U-box containing protein 1; E3 ubiquitin protein ligase;UBOX1.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Extra Details:
- E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Collaborates with ATXN3 in the degradation of misfolded chaperone substrates: ATXN3 restricting the length of ubiquitin chain attached to STUB1/CHIP substrates and preventing further chain extension. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Modulates the activity of several chaperone complexes; including Hsp70; Hsc70 and Hsp90. Mediates transfer of non-canonical short ubiquitin chains to HSPA8 that have no effect on HSPA8 degradation. Mediates polyubiquitination of DNA polymerase beta (POLB) at 'Lys-41'; 'Lys-61' and 'Lys-81'; thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. Mediates polyubiquitination of CYP3A4. Ubiquitinates EPHA2 and may regulate the receptor stability and activity through proteasomal degradation. Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and promotes ubiquitin-mediated protein degradation (PubMed:27708256). Negatively regulates the suppressive function of regulatory T-cells (Treg) during inflammation by mediating the ubiquitination and degradation of FOXP3 in a HSPA1A/B-dependent manner (PubMed:23973223). Likely mediates polyubiquitination and downregulates plasma membrane expression of PD-L1/CD274; an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Negatively regulates TGF-beta signaling by modulating the basal level of SMAD3 via ubiquitin-mediated degradation (PubMed:24613385).
- Gene Details:
- STIP1 homology and U-box containing protein 1
- Host:
- Rabbit
- Immunogen:
- Recombinant Human E3 ubiquitin-protein ligase CHIP protein (1-48AA)
- Isotype:
- IgG
- Protein Details:
- E3 ubiquitin-protein ligase CHIP
- Purity:
- >95%
- Purification:
- Protein G Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
