CAMK1 Antibody
Product Sizes
50ug
£305.00
OACA10545-50UG
100ug
£463.00
OACA10545-100UG
About this Product
- SKU:
- OACA10545
- Additional Names:
- calcium/calmodulin-dependent protein kinase type 1;CaM kinase I;caM kinase I alpha;caM-KI;CAMKI;caMKI-alpha.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Extra Details:
- Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and; upon calcium influx; regulates transcription activators activity; cell cycle; hormone production; cell differentiation; actin filament organization and neurite outgrowth. Recognizes the substrate consensus sequence [MVLIF]-x-R-x(2)-[ST]-x(3)-[MVLIF]. Regulates axonal extension and growth cone motility in hippocampal and cerebellar nerve cells. Upon NMDA receptor-mediated Ca(2+) elevation; promotes dendritic growth in hippocampal neurons and is essential in synapses for full long-term potentiation (LTP) and ERK2-dependent translational activation. Downstream of NMDA receptors; promotes the formation of spines and synapses in hippocampal neurons by phosphorylating ARHGEF7/BETAPIX on 'Ser-694'; which results in the enhancement of ARHGEF7 activity and activation of RAC1. Promotes neuronal differentiation and neurite outgrowth by activation and phosphorylation of MARK2 on 'Ser-91'; 'Ser-92'; 'Ser-93' and 'Ser-294'. Promotes nuclear export of HDAC5 and binding to 14-3-3 by phosphorylation of 'Ser-259' and 'Ser-498' in the regulation of muscle cell differentiation. Regulates NUMB-mediated endocytosis by phosphorylation of NUMB on 'Ser-276' and 'Ser-295'. Involved in the regulation of basal and estrogen-stimulated migration of medulloblastoma cells through ARHGEF7/BETAPIX phosphorylation (By similarity). Is required for proper activation of cyclin-D1/CDK4 complex during G1 progression in diploid fibroblasts. Plays a role in K(+) and ANG2-mediated regulation of the aldosterone synthase (CYP11B2) to produce aldosterone in the adrenal cortex. Phosphorylates EIF4G3/eIF4GII. In vitro phosphorylates CREB1; ATF1; CFTR; MYL9 and SYN1/synapsin I.
- Gene Details:
- calcium/calmodulin dependent protein kinase I
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Calcium/calmodulin-dependent protein kinase type 1 protein (166-265AA)
- Isotype:
- IgG
- Protein Details:
- Calcium/calmodulin-dependent protein kinase type 1
- Purity:
- >95%
- Purification:
- Protein G Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
