CD247 Antibody
Product Sizes
50ug
£305.00
OACA10457-50UG
100ug
£463.00
OACA10457-100UG
About this Product
- SKU:
- OACA10457
- Additional Names:
- CD247 antigen; zeta subunit;CD3H;CD3Q;CD3Z;CD3Z antigen; zeta polypeptide (TiT3 complex);CD3-ZETA;CD3zeta chain;IMD25;T3Z;T-cell antigen receptor complex; zeta subunit of CD3;T-cell receptor T3 zeta chain;T-cell surface glycoprotein CD3 zeta chain;TCR zeta chain;TCRZ.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Extra Details:
- Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR); TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D; CD3E; CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement; these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN; resulting in the activation of downstream signaling pathways (PubMed:2470098; PubMed:7509083). CD3Z ITAMs phosphorylation creates multiple docking sites for the protein kinase ZAP70 leading to ZAP70 phosphorylation and its conversion into a catalytically active enzyme (PubMed:7509083). Plays an important role in intrathymic T-cell differentiation. Additionally; participates in the activity-dependent synapse formation of retinal ganglion cells (RGCs) in both the retina and dorsal lateral geniculate nucleus (dLGN) (By similarity).
- Gene Details:
- CD247 molecule
- Host:
- Rabbit
- Immunogen:
- Recombinant Human T-cell surface glycoprotein CD3 zeta chain protein (88-153AA)
- Isotype:
- IgG
- Protein Details:
- T-cell surface glycoprotein CD3 zeta chain
- Purity:
- >95%
- Purification:
- Protein G Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
