DTL Antibody
Product Sizes
50ug
£305.00
OACA10257-50UG
100ug
£463.00
OACA10257-100UG
About this Product
- SKU:
- OACA10257
- Additional Names:
- CDT2;DCAF2;DDB1- and CUL4-associated factor 2;denticleless protein homolog;L2DTL;lethal(2) denticleless protein homolog;RAMP;RA-regulated nuclear matrix-associated protein;retinoic acid-regulated nuclear matrix-associated protein.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Extra Details:
- Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control; DNA damage response and translesion DNA synthesis. The DCX(DTL) complex; also named CRL4(CDT2) complex; mediates the polyubiquitination and subsequent degradation of CDT1; CDKN1A/p21(CIP1); FBH1; KMT5A and SDE2 (PubMed:16861906; PubMed:16949367; PubMed:16964240; PubMed:17085480; PubMed:18703516; PubMed:18794347; PubMed:18794348; PubMed:19332548; PubMed:20129063; PubMed:23478441; PubMed:23478445; PubMed:23677613; PubMed:27906959). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication (PubMed:16861906; PubMed:16949367; PubMed:17085480). CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing (PubMed:18794348; PubMed:19332548). KMT5A degradation is also important for a proper regulation of mechanisms such as TGF-beta signaling; cell cycle progression; DNA repair and cell migration (PubMed:23478445). Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box; and those containing the 'K+4' motif in the PIP box; recruit the DCX(DTL) complex; leading to their degradation. In undamaged proliferating cells; the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA; thereby being involved in PCNA-dependent translesion DNA synthesis (PubMed:20129063; PubMed:23478441; PubMed:23478445; PubMed:23677613).
- Gene Details:
- denticleless E3 ubiquitin protein ligase homolog
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Denticleless protein homolog protein (393-550AA)
- Isotype:
- IgG
- Protein Details:
- Denticleless protein homolog
- Purity:
- >95%
- Purification:
- Protein G Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
