CASP4 Antibody
Product Sizes
50ug
£305.00
OACA10133-50UG
100ug
£463.00
OACA10133-100UG
About this Product
- SKU:
- OACA10133
- Additional Names:
- apoptotic cysteine protease Mih1/TX;CASP-4;caspase 4; apoptosis-related cysteine peptidase;caspase 4; apoptosis-related cysteine protease;caspase-4;caspase-4 isoform alpha;ICE and Ced-3 homolog 2;ICE(rel)II;ICE(rel)-II;ICEREL-II;ICH-2;Mih1;Mih1/TX;protease ICH-2;protease TX;TX.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Extra Details:
- Inflammatory caspase (PubMed:7797510; PubMed:23516580; PubMed:25119034). Essential effector of NLRP3 inflammasome-dependent CASP1 activation and IL1B and IL18 secretion in response to non-canonical activators; such as UVB radiation; cholera enterotoxin subunit B and cytosolic LPS (PubMed:22246630; PubMed:26174085; PubMed:26173988; PubMed:26508369; PubMed:25964352). Independently of NLRP3 inflammasome and CASP1; promotes pyroptosis; through GSDMD cleavage and activation; and IL1A; IL18 and HMGB1 release in response to non-canonical inflammasome activators (PubMed:24879791; PubMed:25964352). Plays a crucial role in the restriction of Salmonella typhimurium replication in colonic epithelial cells during infection (PubMed:25121752). In later stages of the infection; LPS from cytosolic Salmonella triggers CASP4 activation; which ultimately results in pyroptosis of infected cells and their extrusion into the gut lumen; as well as in IL18 secretion. Pyroptosis limits bacterial replication; while cytokine secretion promotes the recruitment and activation of immune cells and triggers mucosal inflammation. Involved in LPS-induced IL6 secretion; this activity may not require caspase enzymatic activity (PubMed:26508369). Involved in cell death induced by endoplasmic reticulum stress and by treatment with cytotoxic APP peptides found Alzheimer's patient brains (PubMed:15123740; PubMed:22246630; PubMed:23661706). Activated by direct binding to LPS without the need of an upstream sensor (PubMed:25119034). Does not directly process IL1B (PubMed:7743998; PubMed:7797592; PubMed:7797510). During non-canonical inflammasome activation; cuts CGAS and may play a role in the regulation of antiviral innate immune activation (PubMed:28314590).
- Gene Details:
- caspase 4
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Caspase-4 protein (82-226AA)
- Isotype:
- IgG
- Protein Details:
- Caspase-4
- Purity:
- >95%
- Purification:
- Protein G Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
