BTRC Antibody
Product Sizes
50ug
£305.00
OACA10124-50UG
100ug
£463.00
OACA10124-100UG
About this Product
- SKU:
- OACA10124
- Additional Names:
- betaTrCP;BETA-TRCP;beta-TrCP1;bTrCP;bTrCP1;E3RSIkappaB;epididymis tissue protein Li 2a;F-box and WD repeats protein beta-TrCP;F-box and WD-repeat protein 1B;F-box/WD repeat-containing protein 1A;FBW1A;FBXW1;FBXW1A;FWD1;pIkappaBalpha-E3 receptor subunit.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Extra Details:
- Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins (PubMed:10066435; PubMed:10497169; PubMed:10644755; PubMed:10835356; PubMed:11238952; PubMed:11359933; PubMed:11994270; PubMed:12791267; PubMed:12902344; PubMed:14603323; PubMed:14681206; PubMed:14988407; PubMed:15448698; PubMed:15917222; PubMed:16371461; PubMed:25503564; PubMed:25704143; PubMed:9859996). SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling (PubMed:12077367; PubMed:12820959). SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1; ATF4; CDC25A; DLG1; FBXO5; PER1; SMAD3; SMAD4; SNAI1 and probably NFKB2 (PubMed:10835356; PubMed:11238952; PubMed:14681206; PubMed:14603323). SCF(BTRC) mediates the ubiquitination of NFKBIA; NFKBIB and NFKBIE; the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription (PubMed:10066435; PubMed:10497169; PubMed:10644755). Ubiquitination of NFKBIA occurs at 'Lys-21' and 'Lys-22' (PubMed:10066435). SCF(BTRC) mediates the ubiquitination of CEP68; this is required for centriole separation during mitosis (PubMed:25704143; PubMed:25503564). SCF(BTRC) mediates the ubiquitination and subsequent degradation of nuclear NFE2L1 (By similarity). Has an essential role in the control of the clock-dependent transcription via degradation of phosphorylated PER1 and PER2 (PubMed:15917222). May be involved in ubiquitination and subsequent proteasomal degradation through a DBB1-CUL4 E3 ubiquitin-protein ligase. Required for activation of NFKB-mediated transcription by IL1B; MAP3K14; MAP3K1; IKBKB and TNF. Required for proteolytic processing of GLI3 (PubMed:16371461).
- Gene Details:
- beta-transducin repeat containing E3 ubiquitin protein ligase
- Host:
- Rabbit
- Immunogen:
- Recombinant Human F-box/WD repeat-containing protein 1A protein (397-448AA)
- Isotype:
- IgG
- Protein Details:
- F-box/WD repeat-containing protein 1A
- Purity:
- >95%
- Purification:
- Protein G Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
