DMRT1 Antibody
Product Sizes
50ug
£305.00
OACA10122-50UG
100ug
£463.00
OACA10122-100UG
About this Product
- SKU:
- OACA10122
- Additional Names:
- CT154;DM domain expressed in testis 1;DM domain expressed in testis protein 1;DMT1;doublesex- and mab-3-related transcription factor 1.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Extra Details:
- Transcription factor that plays a key role in male sex determination and differentiation by controlling testis development and male germ cell proliferation. Plays a central role in spermatogonia by inhibiting meiosis in undifferentiated spermatogonia and promoting mitosis; leading to spermatogonial development and allowing abundant and continuous production of sperm. Acts both as a transcription repressor and activator: prevents meiosis by restricting retinoic acid (RA)-dependent transcription and repressing STRA8 expression and promotes spermatogonial development by activating spermatogonial differentiation genes; such as SOHLH1. Also plays a key role in postnatal sex maintenance by maintaining testis determination and preventing feminization: represses transcription of female promoting genes such as FOXL2 and activates male-specific genes. May act as a tumor suppressor. May also play a minor role in oogenesis (By similarity).
- Gene Details:
- doublesex and mab-3 related transcription factor 1
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Doublesex- and mab-3-related transcription factor 1 protein (195-363AA)
- Isotype:
- IgG
- Protein Details:
- Doublesex- and mab-3-related transcription factor 1
- Purity:
- >95%
- Purification:
- Protein G Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
