AAK1 Antibody
Product Sizes
50ug
£305.00
OACA10075-50UG
100ug
£463.00
OACA10075-100UG
About this Product
- SKU:
- OACA10075
- Additional Names:
- adaptor-associated kinase 1;AP2-associated protein kinase 1.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Extra Details:
- Regulates clathrin-mediated endocytosis by phosphorylating the AP2M1/mu2 subunit of the adaptor protein complex 2 (AP-2) which ensures high affinity binding of AP-2 to cargo membrane proteins during the initial stages of endocytosis. Isoform 1 and isoform 2 display similar levels of kinase activity towards AP2M1. Regulates phosphorylation of other AP-2 subunits as well as AP-2 localization and AP-2-mediated internalization of ligand complexes. Phosphorylates NUMB and regulates its cellular localization; promoting NUMB localization to endosomes. Binds to and stabilizes the activated form of NOTCH1; increases its localization in endosomes and regulates its transcriptional activity.
- Gene Details:
- AP2 associated kinase 1
- Host:
- Rabbit
- Immunogen:
- Recombinant Human AP2-associated protein kinase 1 protein (274-465AA)
- Isotype:
- IgG
- Protein Details:
- AP2-associated protein kinase 1
- Purity:
- >95%
- Purification:
- Protein G Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
