BIRC3 Antibody
Product Sizes
50ug
£305.00
OACA10074-50UG
100ug
£463.00
OACA10074-100UG
About this Product
- SKU:
- OACA10074
- Additional Names:
- AIP1;API2;apoptosis inhibitor 2;baculoviral IAP repeat-containing protein 3;cellular inhibitor of apoptosis 2;c-IAP2;CIAP2;HAIP1;HIAP1;IAP homolog C;IAP-1;inhibitor of apoptosis protein 1;MALT2;mammalian IAP homolog C;MIHC;RING finger protein 49;RING-type E3 ubiquitin transferase BIRC3;RNF49;TNFR2-TRAF signaling complex protein;TNFR2-TRAF-signaling complex protein 1.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Extra Details:
- Multi-functional protein which regulates not only caspases and apoptosis; but also modulates inflammatory signaling and immunity; mitogenic kinase signaling and cell proliferation; as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling. The target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1; RIPK2; RIPK3; RIPK4; CASP3; CASP7; CASP8; IKBKE; TRAF1; and BCL10. Acts as an important regulator of innate immune signaling via regulation of Toll-like receptors (TLRs); Nodlike receptors (NLRs) and RIG-I like receptors (RLRs); collectively referred to as pattern recognition receptors (PRRs). Protects cells from spontaneous formation of the ripoptosome; a large multi-protein complex that has the capability to kill cancer cells in a caspase-dependent and caspase-independent manner. Suppresses ripoptosome formation by ubiquitinating RIPK1 and CASP8.
- Gene Details:
- baculoviral IAP repeat containing 3
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Baculoviral IAP repeat-containing protein 3 protein (76-245AA)
- Isotype:
- IgG
- Protein Details:
- Baculoviral IAP repeat-containing protein 3
- Purity:
- >95%
- Purification:
- Protein G Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
