AGK Antibody
Product Sizes
50ug
£305.00
OACA09903-50UG
100ug
£463.00
OACA09903-100UG
About this Product
- SKU:
- OACA09903
- Additional Names:
- acylglycerol kinase; mitochondrial;CATC5;CTRCT38;hAGK;hsMuLK;MTDPS10;MULK;multiple substrate lipid kinase;multi-substrate lipid kinase.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Extra Details:
- Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA); respectively (PubMed:15939762). Does not phosphorylate sphingosine (PubMed:15939762). Independently of its lipid kinase activity; acts as a component of the TIM22 complex (PubMed:28712724; PubMed:28712726). The TIM22 complex mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane by forming a twin-pore translocase that uses the membrane potential as the external driving force (PubMed:28712724; PubMed:28712726). In the TIM22 complex; required for the import of a subset of metabolite carriers into mitochtondria; such as ANT1/SLC25A4 and SLC25A24; while it is not required for the import of TIMM23 (PubMed:28712724). Overexpression increases the formation and secretion of LPA; resulting in transactivation of EGFR and activation of the downstream MAPK signaling pathway; leading to increased cell growth (PubMed:15939762).
- Gene Details:
- acylglycerol kinase
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Acylglycerol kinase; mitochondrial protein (32-65AA)
- Isotype:
- IgG
- Protein Details:
- Acylglycerol kinase; mitochondrial
- Purity:
- >95%
- Purification:
- Protein G Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
