BHLHE40 Antibody
Product Sizes
50ug
£305.00
OACA09747-50UG
100ug
£463.00
OACA09747-100UG
About this Product
- SKU:
- OACA09747
- Additional Names:
- basic helix-loop-helix domain containing; class B; 2;BHLHB2;class B basic helix-loop-helix protein 2;class E basic helix-loop-helix protein 40;Clast5;DEC1;differentially expressed in chondrocytes 1;differentially expressed in chondrocytes protein 1;differentiated embryo chondrocyte expressed gene 1;enhancer-of-split and hairy-related protein 2;HLHB2;SHARP2;SHARP-2;stimulated by retinoic acid gene 13 protein;STRA13;Stra14.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Extra Details:
- Transcriptional repressor involved in the regulation of the circadian rhythm by negatively regulating the activity of the clock genes and clock-controlled genes. Acts as the negative limb of a novel autoregulatory feedback loop (DEC loop) which differs from the one formed by the PER and CRY transcriptional repressors (PER/CRY loop). Both these loops are interlocked as it represses the expression of PER1/2 and in turn is repressed by PER1/2 and CRY1/2. Represses the activity of the circadian transcriptional activator: CLOCK-ARNTL/BMAL1|ARNTL2/BMAL2 heterodimer by competing for the binding to E-box elements (5'-CACGTG-3') found within the promoters of its target genes. Negatively regulates its own expression and the expression of DBP and BHLHE41/DEC2. Acts as a corepressor of RXR and the RXR-LXR heterodimers and represses the ligand-induced RXRA and NR1H3/LXRA transactivation activity. May be involved in the regulation of chondrocyte differentiation via the cAMP pathway.
- Gene Details:
- basic helix-loop-helix family member e40
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Class E basic helix-loop-helix protein 40 protein (184-302AA)
- Isotype:
- IgG
- Protein Details:
- Class E basic helix-loop-helix protein 40
- Purity:
- >95%
- Purification:
- Protein G Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
