DCAF1 Antibody
Product Sizes
50ug
£305.00
OACA09731-50UG
100ug
£463.00
OACA09731-100UG
About this Product
- SKU:
- OACA09731
- Additional Names:
- DDB1- and CUL4-associated factor 1;HIV-1 Vpr-binding protein;protein VPRBP;RIP;serine/threonine-protein kinase VPRBP;Vpr (HIV-1) binding protein;Vpr-binding protein;VPRBP;vpr-interacting protein.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Extra Details:
- Acts both as a substrate recognition component of E3 ubiquitin-protein ligase complexes and as an atypical serine/threonine-protein kinase; playing key roles in various processes such as cell cycle; telomerase regulation and histone modification. Probable substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex; named CUL4A-RBX1-DDB1-DCAF1/VPRBP complex; which mediates ubiquitination and proteasome-dependent degradation of proteins such as NF2. Involved in the turnover of methylated proteins: recognizes and binds methylated proteins via its chromo domain; leading to ubiquitination of target proteins by the RBX1-DDB1-DCAF1/VPRBP complex (PubMed:23063525). The CUL4A-RBX1-DDB1-DCAF1/VPRBP complex is also involved in B-cell development: DCAF1 is recruited by RAG1 to ubiquitinate proteins; leading to limit error-prone repair during V(D)J recombination. Also part of the EDVP complex; an E3 ligase complex that mediates ubiquitination of proteins such as TERT; leading to TERT degradation and telomerase inhibition (PubMed:23362280). Also acts as an atypical serine/threonine-protein kinase that specifically mediates phosphorylation of 'Thr-120' of histone H2A (H2AT120ph) in a nucleosomal context; thereby repressing transcription. H2AT120ph is present in the regulatory region of many tumor suppresor genes; down-regulates their transcription and is present at high level in a number of tumors (PubMed:24140421). Involved in JNK-mediated apoptosis during cell competition process via its interaction with LLGL1 and LLGL2 (PubMed:20644714).
- Gene Details:
- DDB1 and CUL4 associated factor 1
- Host:
- Rabbit
- Immunogen:
- Recombinant Human DDB1- and CUL4-associated factor 1 protein (647-745AA)
- Isotype:
- IgG
- Protein Details:
- DDB1- and CUL4-associated factor 1
- Purity:
- >95%
- Purification:
- Protein G Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
