SLC30A10 Antibody
Product Sizes
50ug
£305.00
OACA09585-50UG
100ug
£463.00
OACA09585-100UG
About this Product
- SKU:
- OACA09585
- Additional Names:
- HMDPC;HMNDYT1;manganese transporter SLC30A10;Solute carrier family 30 member 10;zinc transporter 10;zinc transporter 8;ZnT-10;ZNT10;ZNT8;ZRC1.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Extra Details:
- Plays a pivotal role in manganese transport. Manganese is an essential cation for the function of several enzymes; including some crucially important for the metabolism of neurotransmitters and other neuronal metabolic pathways. However; elevated levels of manganese are cytotoxic and induce oxidative stress; mitochondrial dysfunction and apoptosis. Acts as manganese efflux transporter and confers protection against manganese-induced cell death (PubMed:22341972; PubMed:22341971; PubMed:25319704; PubMed:27226609; PubMed:27307044). Also acts as zinc transporter involved in zinc homeostasis. Seems to mediate zinc transport into early endosomes and recycling endosomes to prevent zinc toxicity; the function may be regulated by heterodimerization with other zinc transporters of the SLC30A subfamily. The SLC30A3:SLC30A10 heterodimer is involved in zinc transport-dependent regulation of the EGFR/ERK transduction pathway in endosomes. May be involved in regulation of zinc-dependent senescence of vascular smooth muscle cells (PubMed:22706290; PubMed:22427991; PubMed:26728129).
- Gene Details:
- solute carrier family 30 member 10
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Zinc transporter 10 protein (58-278AA)
- Isotype:
- IgG
- Protein Details:
- Zinc transporter 10
- Purity:
- >95%
- Purification:
- Protein G Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
