TERF2 Antibody
Product Sizes
50ug
£305.00
OACA09551-50UG
100ug
£463.00
OACA09551-100UG
About this Product
- SKU:
- OACA09551
- Additional Names:
- telomeric DNA-binding protein;telomeric repeat binding protein 2;telomeric repeat-binding factor 2;TRBF2;TRF2;TTAGGG repeat-binding factor 2.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Extra Details:
- Binds the telomeric double-stranded 5'-TTAGGG-3' repeat and plays a central role in telomere maintenance and protection against end-to-end fusion of chromosomes. In addition to its telomeric DNA-binding role; required to recruit a number of factors and enzymes required for telomere protection; including the shelterin complex; TERF2IP/RAP1 and DCLRE1B/Apollo. Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded 5'-TTAGGG-3' repeats added by telomerase and protects chromosome ends; without its protective activity; telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Together with DCLRE1B/Apollo; plays a key role in telomeric loop (T loop) formation by generating 3' single-stranded overhang at the leading end telomeres: T loops have been proposed to protect chromosome ends from degradation and repair. Required both to recruit DCLRE1B/Apollo to telomeres and activate the exonuclease activity of DCLRE1B/Apollo. Preferentially binds to positive supercoiled DNA. Together with DCLRE1B/Apollo; required to control the amount of DNA topoisomerase (TOP1; TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Recruits TERF2IP/RAP1 to telomeres; thereby participating in to repressing homology-directed repair (HDR); which can affect telomere length.
- Gene Details:
- telomeric repeat binding factor 2
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Telomeric repeat-binding factor 2 protein (78-238AA)
- Isotype:
- IgG
- Protein Details:
- Telomeric repeat-binding factor 2
- Purity:
- >95%
- Purification:
- Protein G Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
