ASPN Antibody
Product Sizes
50ug
£305.00
OACA09339-50UG
100ug
£463.00
OACA09339-100UG
About this Product
- SKU:
- OACA09339
- Additional Names:
- asporin;asporin (LRR class 1);asporin proteoglycan;OS3;periodontal ligament associated protein 1;Periodontal ligament-associated protein 1;PLAP1;PLAP-1;SLRR1C;small leucine-rich protein 1C.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Extra Details:
- Negatively regulates periodontal ligament (PDL) differentiation and mineralization to ensure that the PDL is not ossified and to maintain homeostasis of the tooth-supporting system. Inhibits BMP2-induced cytodifferentiation of PDL cells by preventing its binding to BMPR1B/BMP type-1B receptor; resulting in inhibition of BMP-dependent activation of SMAD proteins (By similarity). Critical regulator of TGF-beta in articular cartilage and plays an essential role in cartilage homeostasis and osteoarthritis (OA) pathogenesis. Negatively regulates chondrogenesis in the articular cartilage by blocking the TGF-beta/receptor interaction on the cell surface and inhibiting the canonical TGF-beta/Smad signal. Binds calcium and plays a role in osteoblast-driven collagen biomineralization activity.
- Gene Details:
- asporin
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Asporin protein (33-380AA)
- Isotype:
- IgG
- Protein Details:
- Asporin
- Purity:
- >95%
- Purification:
- Protein G Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
