CRBN Antibody
Product Sizes
50ul
£316.00
OACA09276-50UL
100ul
£387.00
OACA09276-100UL
About this Product
- SKU:
- OACA09276
- Additional Names:
- MRT2;MRT2A;protein cereblon;protein x 0001.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Extra Details:
- Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins; such as MEIS2. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8. May play a role in memory and learning by regulating the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. Binding of pomalidomide and other thalidomide-related drugs changes the substrate specificity of the human protein; leading to decreased degradation of MEIS2 and other target proteins and increased degradation of MYC; IRF4; IKZF1 and IKZF3.
- Gene Details:
- cereblon
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Protein cereblon protein (1-280AA)
- Isotype:
- IgG
- Protein Details:
- Protein cereblon
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
