GBF1 Antibody
Product Sizes
50ul
£316.00
OACA09210-50UL
100ul
£387.00
OACA09210-100UL
About this Product
- SKU:
- OACA09210
- Additional Names:
- ARF1GEF;BFA-resistant GEF 1;Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1.
- Clonality:
- Polyclonal
- Conjugate:
- Unconjugated
- Extra Details:
- Guanine-nucleotide exchange factor (GEF) for members of the Arf family of small GTPases involved in trafficking in the early secretory pathway; its GEF activity initiates the coating of nascent vesicles via the localized generation of activated ARFs through replacement of GDP with GTP. Recruitment to cis-Golgi membranes requires membrane association of Arf-GDP and can be regulated by ARF1; ARF3; ARF4 and ARF5. Involved in the recruitment of the COPI coat complex to the endoplasmic reticulum exit sites (ERES); and the endoplasmic reticulum-Golgi intermediate (ERGIC) and cis-Golgi compartments which implicates ARF1 activation. Involved in COPI vesicle-dependent retrograde transport from the ERGIC and cis-Golgi compartments to the endoplasmic reticulum (ER) (PubMed:16926190; PubMed:17956946; PubMed:18003980; PubMed:12047556; PubMed:12808027; PubMed:19039328; PubMed:24213530). Involved in the trans-Golgi network recruitment of GGA1; GGA2; GGA3; BIG1; BIG2; and the AP-1 adaptor protein complex related to chlathrin-dependent transport; the function requires its GEF activity (probably at least in part on ARF4 and ARF5) (PubMed:23386609). Has GEF activity towards ARF1 (PubMed:15616190). Has in vitro GEF activity towards ARF5 (By similarity). Involved in the processing of PSAP (PubMed:17666033). Required for the assembly of the Golgi apparatus (PubMed:12808027; PubMed:18003980). The AMPK-phosphorylated form is involved in Golgi disassembly during mitotis and under stress conditions (PubMed:18063581; PubMed:23418352). May be involved in the COPI vesicle-dependent recruitment of PNPLA2 to lipid droplets; however; this function is under debate (PubMed:19461073; PubMed:22185782). In neutrophils; involved in G protein-coupled receptor (GPCR)-mediated chemotaxis und superoxide production. Proposed to be recruited by phosphatidylinositol-phosphates generated upon GPCR stimulation to the leading edge where it recruits and activates ARF1; and is involved in recruitment of GIT2 and the NADPH oxidase complex (PubMed:22573891).
- Gene Details:
- golgi brefeldin A resistant guanine nucleotide exchange factor 1
- Host:
- Rabbit
- Immunogen:
- Recombinant Human Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1 protein (1-85AA)
- Isotype:
- IgG
- Protein Details:
- Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1
- Purification:
- Affinity Purified
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- -20Â[o]C or -80Â[o]C
- Supplier:
- Aviva Systems Biology
- Type:
- Antibodies: Polyclonal Antibody
- Manufacturer's Data Sheet:html_datasheet.php
